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For instance, reduced expression of PER1 and CRY1 has been associated with higher tumor grade and poor prognosis 27

GH exerts autocrine/paracrine effects by binding to GHR in the same or a neighboring cell surface and initiating JAK2- and SRC-mediated signaling cascades, which decrease pro-apoptotic molecules (Bax and PPAR) and suppress caspase protein activation (Figure 4A)
Li S, Wang Y, Matsumura K, Ballou LR, Morham SG, Blatteis CM

, Rong P., Yang Y., et al
