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Finally, to overcome the limitations of IR-820, IR-820@NBs were developed, which target mitochondria under ultrasound to generate lethal ROS, 450 while in combination with proteasome inhibitors, MG-132 further enhances SDT efficacy by inducing apoptosis and autophagy in HCC cells

Although most of these proteins are associated with metabolism and have not been previously linked to synaptic mechanisms of learning and memory, several proteins, including dual-specificity protein phosphatase 3, calmodulin, and NSF, are implicated in synaptic signaling, demonstrating the importance of synaptic function and maintenance in cognitive function