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A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

ethinyl estradiol and norethindrone Chloramphenicol (used to manage bacterial infections) Cimetidine (used to manage ulcers of the stomach and intestines) Overdosage: ME 12 500MCG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose

Conclusions Physical and psychosocial PROMs diverge in people with MS 55 years and older as they age, with increased physical limitations but improved mental health over time

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