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Lack of Nrf2 can increase the sensitivity and severity of different respiratory conditions such as BPD, adult respiratory distress syndrome, chronic obstructive pulmonary disease, asthma, and lung cancer, whereas activation of Nrf2 protects against various respiratory diseases (47)

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NO activates soluble guanylate cyclase [174], resulting in the generation of cGMP, which in turn activates cGKI [175]

In MI, brain-mediated SNS overdrive and HPA activation exacerbate infarct size and arrhythmogenesis, 139 whereas poststroke cardiac dysfunction (e.g., Takotsubo cardiomyopathy) reflects ANS dysregulation, with catecholamine surges weakening myocardial contractility