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In moderate to severe cataplexy, pharmacological treatment is usually required (serotoninnorepinephrine reuptake inhibitors such as venlafaxine and sodium oxybate)

Lombardo M, Feraco A, Ottaviani M, et al

Even though experimental and observational studies show a significant correlation between elevated levels of plasma TMAO and adverse cardiovascular events, the precise mechanism is still in place and unidentified [11]

In fact, no clinically relevant analgesic efficacy of low-dose naltrexone treatment was observed in these patients when using the revised Fibromyalgia Impact Questionnaire scores and the sum of pain intensity ratings as primary outcomes