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CRISPR Therapeutics and Vertex, the makers of Casgevy, as well as a number of other groups developing treatments for these disorders, treated the disorders by turning on fetal hemoglobin (HbF), a kind of hemoglobin usually only found in fetuses and very young infants
Cystine limitation increased phospho-GCN2 (T899), but not that of PERK (as no visible mobility shift was observed) (Fig
