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If left untreated, the capillary leakage and subsequent retinal hypoxia promote neovascularization [19], which manifests as PDR

Impact of aerobic exercise and fatty acid supplementation on global and gene-specific DNA methylation

doi: 10.1242/dev.01725

Meanwhile, clinical interventions can significantly modulate the composition of gut microbiota, and alteration in gut microbiota may subsequently indicate susceptibility to pulmonary infections and even contribute to the prevention or regulation of their progression
