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Porphyrins, undergoing the oxidation process on the skin surface, release proinflammatory substances, which ultimately promote the development of acne-like lesions [100,101,102,103,104,105], which may leave permanent scars [97]

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Desensitization is a recommended therapeutic strategy, especially when drug hypersensitivity occurs via an immediate IgE-dependent hypersensitivity reaction (type I hypersensitivity reaction)