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Tenofovir alafenamide versus tenofovir disoproxil fumarate for the treatment of HBeAg-positive chronic hepatitis B virus infection: a randomised, double-blind, Phase III, non-inferiority trial
[PubMed: 3987069] 400
In addition, HIF-1 can regulate numerous signaling pathways, such as GSK3/mitochondrial PTP, -catenin, ERK1/2, Bcl-2, PI3K/AKT and mTOR, which are involved in the regulation of broad-spectrum cell functions, and thus can decrease the severity of MIRI (5457)
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