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Inhibition of upstream activators of the JNK pathway, including kRas, Rac/cdc42 and mixed lineage kinases also provides protection to HCs (Bodmer et al., Apoptosis Following the activation of MAPK and ROS stress pathways, cochlear HCs can undergo apoptosis following intense noise exposure, aminoglycoside or cisplatin ototoxicity, or aging (Hu et al., 2000, 2002a,b
