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General clinical guidance often includes: Dividing the dose (for example, morning and evening) to improve tolerance Taking NAC away from food if tolerated, as absorption may be better on an empty stomach Using NAC as part of a long-term strategy , since its benefits are related to ongoing antioxidant and anti-inflammatory support Some research protocols have used NAC cyclically (such as several days per week), while others use daily dosing

doi: 10.1093/humrep/des013 23 HortonJSterrenburgMLaneSMaheshwariATCLiCheongY

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However, if you have a sensitive stomach, taking it with a small meal is also effective, especially when using a liposomal format that is designed for easy digestion