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Description
A role for neuronal NHR-49 in longevity is supported by tissue-specific rescue studies of lifespan in a double mutant of nhr-49 with the long-lived, germline less glp-1/Notch receptor mutant: although expression of NHR-49 from intestine, hypodermis, and body wall muscle specific promoters all partially rescued glp-1 longevity, expressing NHR-49 pan-neuronally completely restored long lifespan (Naim et al., 2021)
Substantial efforts are required to uncover the role of other chloride channels in the pathogenesis of CIPN
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