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The article also deals at some length with nonenzymatic and enzymatic processes that divert glutathione S -conjugate and cysteine S -conjugate away from the mercapturate pathway

Am J Physiol Endocrinol Metab 287 : E405E413 Guo Y et al

Medical relevance of common protein-altering variants in GPCR genes across 337,205 individuals in the UK Biobank

In chemically induced liver injury modelsincluding carbon tetrachloride (CCl 4 ), acetaminophen (APAP), cadmium (Cd), and alcohol (AA) exposureGLPs activate the Nrf2Keap1 antioxidant axis, leading to nuclear translocation of Nrf2 and subsequent upregulation of heme oxygenase-1 (HO-1) and downstream phase II enzymes