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Then, these AP sites are cleaved by an AP endonuclease

Effects of Dopamine on the Glutathione Metabolism of Cultured Astroglial Cells: Implications for Parkinson's Disease. Journal of Neurochemistry 82: 458467

Summary In summary, for forty years abnormally elevated dopamine has been noted in the body fluids of people with autism and was treated with dopamine receptor blocking drugs like risperidone and haloperidol

NO generated in endothelial cells diffuses rapidly to adjacent smooth muscle cells, which activates soluble guanylate cyclase (sGC) and allows the conversion of GTP to cyclic GMP, initiating a signaling cascade leading to vasodilation [8, 9]