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Enhanced p53 Activation by MDM2 and XPO1 Disrupts MYC Transcriptional Program and Profoundly Synergizes to Induce Apoptosis in Combination with BCL-2 Inhibition in Ven/HMA Resistant Acute Myeloid Leukemia

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The clinical success of dental implants primarily depend on the direct structural and functional connection between the living bone and the implant surface, which is referred to as osseointegration ( 5 NAC combined with biomaterials for bone tissue engineering Bone tissue, a highly organized natural composite material, integrates organic and inorganic substances with various cell types within the extracellular matrix (ECM) scaffold ( Polymethyl methacrylate (PMMA) bone cement is extensively used in orthopedic surgery, but the high elastic modulus and low biocompatibility have limited further advancements ( in vitro and in vivo experiments (Table 5 and Figure 2)