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Description
GSH reduces the oxidized catalytic cysteine (Cys47-SOH) of PRDX6, sustaining its peroxidase activity against lipid peroxides, like GPX4, and linking PRDX6 directly to ferroptosis resistance (Fig
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2006(3):CD004736
During this process, instead of ADH, cytochrome P450 2E1 (CYP2E1) is activated in the liver to break down acetaldehyde [6]
