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Oncogene (2021) 40(49):666679

Preclinical studies indicate potential roles in: Supporting healthy fat metabolism and reduction of adipogenesis Improving insulin sensitivity in metabolic research models Enhancing NAD+ salvage pathway efficiency Exploring effects on energy homeostasis and longevity pathways These findings remain preliminary and confined to laboratory and animal models

Second, catecholamine levels and sympathetic nervous system activity are relatively elevated in the early morning, providing a favourable hormonal backdrop for beta-3 adrenergic activation