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When growth hormone receptors become more abundant on cell surfaces, each molecule of circulating growth hormone produces a stronger effect

In skeletal muscle, decreased Akt activity prevents the glucose transporter GLUT4 from translocating from intracellular vesicles to the cell membrane, significantly reducing glucose uptake (89, 90)

H.LeeH.KimD.et al (2015)

This modest requirement reflects the body's efficient recycling mechanisms and substantial liver storage capacity
