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Healthy cells generally have a GSH/GSSG ratio of greater than 100, while cells under oxidative stress exhibit a ratio of about 1:10substantially lower

[38,39] Geroprotective effect of Metformin has been reported in multiple animal models including lifespan extension in Caenorhabditis elegans , Drosophila melanogaster and mice, and deceleration of aging clocks in male nonhuman primates

These processes have been described in the healing of tendons, muscles, and skin wounds, suggesting that the mechanism of action is not limited to a specific tissue type but rather involves general cellular regulatory pathways