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Combining oral collagen with a topical retinoid or vitamin C serum often yields superior results because topical agents drive cellular turnover and surface improvement while oral agents support structural rebuilding

On the other hand, when O 2 -and H 2 O 2 are present in the cytosol, Fe 3+ can be converted to Fe 2+ , which is also known as the HaberWeiss reaction and is the driving force of the Fenton reaction

In Gclc -KO liver, the GSH level is less than 5%, but in Chac1 -overexpression mice, the liver GSH level is approximately 15%, which is sufficient to maintain normal liver function and mitochondrial respiration (14)

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