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The ODC1 mRNA contains a long 5-untranslated region (5-UTR) that folds into a complex secondary structure

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Therefore, the management tries to address these two components, which can combined or include the following: Cognitive behavioral treatment Topical medications (e.g., benzodiazepine, anticonvulsants, anesthetics, among others) Systemic medications (e.g., Tricyclic antidepressants, antiepileptics benzodiazepines, among others) Over the counter vitamins and supplements Over-the-Counter Options to Consider for BMS Management Topical capsaicin rinse Several studies have reported that topical capsaicin is an analgesic for treating BMS with positive results

Further studies are required to determine the role of VEGF in PN-related itching