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The causative factors contributing to the onset and development of complex and multigenic neurodegenerative diseases have been attributed to genetic and environmental factors (Brown et al

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5.2 Shortcomings of TCM in clinical studies Although TCM is currently receiving increasing attention worldwide as an alternative and complementary therapy for cancer treatment, there are some limitations in the published studies, such as the lack of scientific validity of the studies with large samples, multi-centre participation, randomised control and efficacy comparisons

This local iron overload in DSCs triggers ferroptosis through reduced GSH and glutathione peroxidase four levels with the concomitant increase in lipid and cellular ROS