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LPS are important regulators of these diseases, as long-term LPS administration to mice has induced weight gain, insulin resistance, and increased intestinal permeability (113)

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Elevated serum BAFF levels are associated with rising anti-double-stranded DNA antibody levels and disease flare following B cell depletion therapy in systemic lupus erythematosus

Dietary or gavage administration of isothiocyanates, flavonoids, and other phytochemicals to animals, with even moderate degrees of control, provides consistent changes in biomarkers and usually phenotypic benefit, which adds strength to causal inference
