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Conversely, overfeeding increases intra-portal insulin levels that enhances hepatic GH sensitivity to a degree where relatively low GH secretion is sufficient to maintain ambient hepatic IGF-I synthesis and secretion, and normal circulating IGF-I levels ( Figure 1 This review summarizes how changes in hepatic exposure to intra-portal insulin in health and disease states modulates the GH/IGF-I axis

*Correspondence: Junping Zhen, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

microplus , no significant differences were observed in terms of tick mortality and oviposition when GST is knocked down [46]

This is a precautionary concern