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The GLP-1R, present in glutamatergic neurons in hypothalamic nuclei such as the arcuate nucleus and the paraventricular nucleus (PVN), contributes to the increased hepatic FGF21 most likely via direct autonomic nervous system circuits from the brain to the liver

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Funding This work was supported by the Research Foundation of Akdeniz University, Antalya, Turkey under Grant number TSA-2017-2884

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