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In oncology, pre-clinical gastric-, lung- and hepatocellular-cancer models reveal that pharmacological melatonin down-regulates tumour and myeloid PD-L1, remodels TAMs toward an IL-12 high/iNOS + M1 phenotype, and boosts CD8 + T-cell infiltrationchanges that synergistically enhance anti-PD-L1 checkpoint blockade

Pigmented SCC can present a dermatoscopic pattern resembling melanocytic lesions with globules, radial streaks and homogeneous blue pigmentation and can lead a physician to a wrong diagnosis

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Treatment of Philadelphia chromosome positive (Ph+) chronic myelogenous leukemia in blast crisis and Ph+ acute leukemia with high dose cytosine arabinoside (HDARAC)