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This approach works well, yet it can have a significant stinging sensation, as well as potential stiffness after the procedure

While the question of the musical expression of emotion has a long history of investigation, including in PNAS (6), and the 1990s psychophysiological strand of research had already established that musical pleasure could activate the autonomic nervous system (7), the authors' demonstration of the implication of the reward system in musical emotions was taken as inaugural proof that these were veridical emotions whose study has full legitimacy to inform the neurobiology of our everyday cognitive, social, and affective functions (8)

Although current data support the notion that HDACi overcomes resistance through epigenetic regulation and inhibition of pro-survival pathways, the limitations of small sample sizes and non-randomized designs necessitate validation through larger-scale studies (102)