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Daniel P, Sabri S, Chaddad A, Meehan B, Jean-Claude B, Rak J, et al

Signal integration is accomplished by the assembly of cytosolic pattern recognition receptors (PRRs), including nucleotide oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 1 (NLRP1), NLRP3, NLRC4, absent in melanoma 2 (AIM2), and pyrin, and activation of caspase-1

5.1 Pharmacological approaches Pharmacological interventions in macrophage polarization employ diverse targeting strategies to remodel the immune microenvironment by modulating key signaling pathways and metabolic reprogramming ( Figure 5 )

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