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Furthermore, the patients with OIPN are more likely to benefit from duloxetine than patients with a paclitaxel-induced neuropathy based on an exploratory responder analysis [182], which suggests that action of duloxetines pharmacodynamic effect may be tightly associated with specific molecular mechanisms underlying OIPN [183, 184]
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Vargas MR, Burton NC, Gan L et al (2013) Absence of Nrf2 or its selective overexpression in neurons and muscle does not affect survival in ALS-linked mutant hSOD1 mouse models
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