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Allopurinol has a higher risk of severe skin reaction in people with kidney function abnormality, and people with this abnormality are often the ones on febuxostat

Other groups of people who have a higher risk include people over age 60, people on certain medications for diabetes, people with Crohns disease, celiac, ulcerative colitis and irritable bowel syndrome and women with a history of infertility or miscarriage

Do you experience weakness or fatigue

The choice between them for glycemic control alone would likely favor tirzepatide simply because it is available and proven, while retatrutide remains investigational