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AOD 9604 and Cartilage / Joint Research Interest in AOD 9604 later shifted toward cartilage repair and osteoarthritis models : In a collagenase-induced knee osteoarthritis (OA) rabbit model , weekly intra-articular injections of AOD 9604 (0.25 mg), with or without hyaluronic acid (HA), enhanced cartilage regeneration compared with saline controls

at the cellular level this reprograms metabolic signaling (e.g., sirtuin-dependent pathways) and has been shown in vitro and in rodent studies to lower 1-MNA , reduce adipocyte lipogenesis/size , and increase energy expenditure

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Based on pill count, the compliance with treatment was 99.3 1.5%, 97.8 3.8% and 97.1 6.7%, respectively