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Common side effects (such as dizziness, somnolence, and peripheral oedema) can significantly impact the quality of life and daily functioning of patients with fibromyalgia

doi: 10.1038/s41598-018-23408-0 27 HadianKStockwellBR

Brain-to-plasma exposure metrics, such as K p, brain , may provide a useful measure of total brain exposure relative to systemic exposure, while K p, uu, brain , where feasible, may offer a more informative assessment of unbound brain exposure at the BBB

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