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REDEFINE 1 Results (Phase 3) The landmark trial randomized 3,417 adults to CagriSema 2.4/2.4 mg, semaglutide 2.4 mg alone, cagrilintide 2.4 mg alone, or placebo for 68 weeks (Aronne et al., 2025): The combination significantly outperformed either component alone

This 83-amino-acid polypeptide features a key structural modification: a substitution of arginine for glutamic acid at position 3, along with a 13-amino-acid N-terminal extension

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That is, a trans -1,2-diol results when an epoxycycloalkane is opened by aqueous acid, just as a trans -1,2-dibromide results when a cycloalkene is brominated