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In contrast, the M1-phenotype macrophage marker genes, including CD86 , IL-1 , inducible nitric oxide synthase (iNOS) , and tumor necrosis factor (TNF)- , were remarkably decreased in the Se@PA and SeC@PA(+) groups (Supplementary Fig

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This regulatory function is particularly evident in tumor biology, where amino acid metabolic reprogramming critically influences cancer cell proliferation, survival, and interactions with the immune system

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This maintains the pulsatile release pattern that matters for optimal effects

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PMID: 10736351

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