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However, existing medical methods (e.g., antidepressants) have a response rate of only 50% in MDD patients (6), and early clinical symptoms of depression (e.g., anhedonia, sleep disturbance) are often ignored, further worsening health outcomes

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CD49a, the alpha subunit of the 11 integrin, also known as very late antigen 1 (VLA-1), serves as the primary receptor for type IV collagen located on the basement membrane of the skin [83]

The study demonstrated elevated levels of pro-inflammatory cytokines, such as IL-1 and TNF-, in the brains of CKD mice, indicating that gut-derived signals play a central role in mediating neuroinflammation in CKD (Andrade-Oliveira et al., 2015)