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The Science Behind the Success How GLP-1/GIP + B12 Works Tirzepatide activates two hormone pathways (GLP-1 + GIP), improving blood sugar control and appetite regulation simultaneously
On the other hand, it activates HIF-1, which transcriptionally upregulates VEGF to promote tumor angiogenesis [394]
The dual action creates a net negative fat balance: more fat is broken down, less new fat is formed (Ng et al., 2000)
