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GPX4 is expressed in different cell types and tissues as three distinct cellular isoforms, namely mitochondrial GPX4 (mGPX4), cytoplasmic GPX4 (cGPX4), and nuclear GPX4 (nGPX4,) that are encoded by the same gene and generated using alternate promoters or alternative splicing

Nonviral gene delivery systems are advantageous compared to virus transfection because these methods can avoid mutations caused by retroviral gene transfection and reduce the immune response

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Generally inactive and undifferentiated, these cells are considered crucial as a potential source for future cell differentiation