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This triggered intense investigation in the field due to the immense therapeutic potential of biased compounds (Seyedabadi et al., 2019) (Fig
Role of NAD+, oxidative and tryptophan metabolism in autism spectrum disorders
89 When mitochondrial fusion is suppressed by the down-regulation of OPA1, resulting in elevated ROS levels while an decrease in antioxidant enzyme levels, finally contributing to oxidative stress and cellular damage
When cardiolipin is damaged by oxidation, energy production becomes less efficient and ROS can rise further
