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In response to ER stress, GSH levels are depleted due to the accumulation of misfolded proteins and increased ROS production [52]

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[25] Murine cells overexpressing the NADase CD38 consumed less oxygen, had higher lactate levels, and had abnormal mitochondria, including traits like missing or enlarged cristae, which lends more proof of NAD+s role in promoting mitochondrial and metabolic health
