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The intend to reduce oxidative-stress and the up-regulation of pro-inflammatory cytokines due to chemotherapy have led many authors to test antioxidant therapy
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70 As a result, STAT3-dependent ZIP6 expression leads to downstream activation of the transcriptional repressor Snail, which contributes to the epithelial-mesenchymal transition (EMT) during embryonic development and is associated with tumor metastasis mechanisms (Fig
