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From the pathogenic point of view, the questions to be answered are many and should address the predisposing genetic background, the trigger(s) as well as the mechanisms involved in the initiation, and further development of both fibrosis and vasculopathy simultaneously taking into account clinical heterogeneity (Fig

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Additionally, for scenarios involving acute exacerbation on a background of chronic macrocytic anemia, the relevant code to consider is D63.8 along with the appropriate modifier