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Description
We previously also established a valid HUA animal model to explore urate-lowering therapy and organ protection ( 2 Materials and methods 2.1 Cardiomyocyte generation and treatment Cardiomyocytes were differentiated from hESCs (H1 cell line)

Compared with the control group, the triglyceride (TG) content was significantly decreased in the carnitine supplementation group in the liver and muscle in both the feeding and fasting states
Glutamate and -ketoglutarate levels, on the other hand, were diminished after ELAVL1 knockdown or telaglenastat treatment, and the effect was more pronounced with both ELAVL1 knockdown and telaglenastat treatment combined (Fig

[DOI] [PubMed] [Google Scholar] 199.Ridker P.M., Cook N
