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The Underlying Toxic Mechanism of Gliotoxin Gliotoxin can induce cytotoxicities via different mechanisms, including the inhibition of angiogenesis, immunosuppressive activity, the inducement of cell apoptosis, the suppression of the activity of protease, the production of ROS and the inhibition of the enzymatic activity of peroxidases, the imbalance of oxireductase reaction, the induction of DNA damage, and the repression of specific genes expression, including NF-B factor [6]

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Pralidoxime's effects may be intensified in patients with kidney disease

Inflammopharmacology, 7(1), 114