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The allometric approach is a less complicated empirical approach developed based on the cross species similarities in biology, physiology, and anatomy utilizing a power function correlating physiological parameters with body size.19 The allometric projections have been demonstrated to work well for small molecules, especially those that primarily undergo renal elimination.14 However, when small molecule drugs display high crossspecies variability in PKs (e.g., due to metabolism), this method may not work well

During the active stage of ischemia and the response of late-response genes, i.e., 24 h after pMCAO, we observed increased levels of transcripts encoding transmembrane receptors and enzymes, especially cytokines and immunoglobulins

Absorbance at 283 nm (A 283 ) was recorded and values corrected for dilution factors

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