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These proinflammatory molecules also induce the above lesions through the nuclear factor-B (NF-B), Janus kinase/signal transducers and activators of transcription (JAK/STAT), and TGF-/Smad signaling pathways[99-101]

The DMPD assay is particularly well-suited for assessing hydrophilic antioxidants but is less responsive to hydrophobic bioactive compounds, a limitation not shared by other assays

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For example, it has been demonstrated that compared with adjacent normal tissues, the monounsaturated fatty acids (MUFAs) level in TC tissues is significantly elevated in TC [103], along with that, the serum level of MUFAs is decreased [104]