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The increasing A aggregation also led to the release of nitric oxide, reactive oxygen species (ROS), and proinflammatory cytokines which are factors that may contribute to neuronal death ( APOE4 difference from other APOE isoforms Apolipoprotein E (APOE) is a protein that transports cholesterol and lipids

Traverso N, Ricciarelli R, Nitti M, et al

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There was a minimal periosteum reaction and few mesenchymal cells only after the end of the first week
