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2013;8:e53353
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However, due to the instability of oligonucleotides (half-life less than 1 min), chemical modifications are mandatory, such as the substitution of 2-hydroxyl of the ribose moiety in pyrimidiones by an amino group or fluorine to ameliorate the nuclease resistance to hydrolysis and the replacement of 2-hydroxyl position of purines by 2- O -methyl [19]
In a study by Kaewkod et al
