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After menopause, the decline in estrogen, accompanied by a decrease in HDL-C and an increase in LDL-C, exacerbates oxidative stress-related depressive symptoms (40)

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Central appetite suppression: Amylin crosses blood-brain barrier Activates area postrema (brainstem) Also acts on nucleus accumbens Direct satiety signaling Reduces desire to eat Different brain pathways than GLP-1 3

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