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GSH levels were also found to be decreased in the frontal cortex of patients with AD, and the GSH reductions in these regions were correlated with the decline in cognitive functions [100]

Yet as our understanding of cellular signaling and regulatory pathways has developed, so has our insight into the involvement of GSH homeostasis in many other key processes, including the regulation of cellular proliferation and apoptosis and the post-transcriptional modification of proteins through S-glutathionylation, as well as the importance of GSH in the detoxification of hydroperoxides and diverse xenobiotic compounds

The peak at 308 m /z (Fig