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Pre-conditioning with phenolic sulfates improved cellular responses to oxidative, excitotoxicity and inflammatory injuries and this attenuation of neuroinflammation was achieved via modulation of NF-B pathway
NPs can be endocytated and induce autophagy activation and autophagosome formation, particularly in neurons, which are more susceptible to NPs exposure related stress and degeneration [19]
Chronic L2-Cmu treatment is well tolerated in older mice We next performed a 6 mo feasibility study with weekly L2-Cmu i.p
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